Model PRB-5079 - Cas9 (CRISPR Associated Protein 9) ELISA Kit - Manual

Cas9 (CRISPR associated protein 9) is an RNA-guided DNA endonuclease. This enzyme associates with the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) adaptive immunity system in various types of bacteria including Streptococcus pyogenes. Cas9 is able to unwind foreign DNA (such as plasmid DNA or invading bacteriophage DNA) and then checks for sites complementary to the 20 base pair spacer region of the guide RNA. If the DNA substrate is complementary to the guide RNA, Cas9 cuts up invading DNA.