Mass Spectrometry Articles

  • Webinar Highlights: Microfluidics for macromolecules

    Hi, I’m Jim Murphy, Principal Consulting Chemist at Waters, and I recently collaborated with Lucinda (Cohen) Hittle to present an exciting webinar on the use of microflow chromatography for macromolecules.  Lucinda, a Director of Discovery Bioanalytics at Merck, presented an overview of the use of LC-MS for peptide analysis along with various case studies for in vitro and in vivo ...


    By Waters Corporation

  • Analysis of Trace Elements in Water by EPA Method 200.8 using ICP Mass Spectrometry

    This application note describes the methodology and use of the Shimadzu ICPMS-2030 ICP mass spectrometer for the analysis of trace elements in drinking and fresh waters following the EPA 200.8 method. This method is also used for analysis of wastewater. In-line addition of internal standards to calibration and unknown samples was accomplished using the Shimadzu Internal Standard Addition ...

  • Is Microflow LC a Reality or Perception?

    Microflow or nanoflow chromatography has been used mostly in the academic and fundamental research environment in the past for its various advantages over analytical liquid chromatography, but rarely in the industrial settings. This is most likely because many of us believe it is a pain-in-the-neck technique to perform! But is this a reality or just a ...


    By Waters Corporation

  • Fast analysis of semi-volatile organic compounds using PTV-GC–TOF MS

    The evaluation of semi-volatile organic compounds (SVOCs) in environmental matrices poses many challenges for the analyst, not least the vast number that may be encountered in any given analysis. In addition, analyte reactivity and the potential for multiple analytes to co-elute makes achieving the required method detection limits (LODs or MDLs) quickly and cost-effectively a formidable task ...


    By SepSolve Analytical

  • Detailed characterisation of essential oils by flow-modulated GC×GC and Tandem Ionisation mass spectrometry

    Volatile oils of plants, also known as essential oils, have been used for many years for their flavour, fragrance and medicinal properties. However, their extreme complexity and diversity presents analysts with a significant challenge when it comes to quality control. They are generally composed of monoterpenes and sesquiterpenes, as well as their oxygenated derivatives, such as aliphatic ...


    By SepSolve Analytical

  • What is microflow?

    What are the differences between micro-scale and conventional LC? Microflow (aka micro-scale) LC/MS has been widely applied to proteomic research for years.  Recently, as microflow LCMS systems continue to evolve, more and more laboratories in various fields are weighing the implications of applying this small-is-beautiful technology. In this and my next two blog posts, ...


    By Waters Corporation

  • In Beverly, the Shoe Fits for Bioanalysis!

    This past May, many of the nation’s leading bioanalysts gathered in New England to share ideas and explore the latest advances in mass spectrometry, liquid chromatography, and sample preparation for large molecule quantification. At Waters’ semi-annual bioanalysis workshop, scientists from across the U.S. trained on the latest mass spectrometry instrumentation at our demonstration ...


    By Waters Corporation

  • Do You See What We See? Mass Spectrometry Imaging is Revealing Insights in Biomedical Research

    The spatial distribution of molecular species in a sample can provide a wealth of information about biological, chemical and physiological processes. Mass spectrometry (MS) imaging is a rapidly developing research technique that enables specific measurement of molecular targets at complex surfaces. This direct-from-sample analytical technique provides researchers with the information needed to ...


    By Waters Corporation

  • NASA campaign KORUS-AQ: IONICON PTR-TOF to monitor VOCs above Korea

    Team of the University of Innsbruck and an IONICON PTR-TOFMS aboard NASA research aircraft An international team coordinated by NASA has recently investigated air pollution over the Korean peninsula. Two of IONICON’s PTR-TOFMS instruments were used to monitor volatile organic compounds (VOCs) in real-time aboard NASA’s DC-8 Flying Laboratory. The data gathered by scientists ...


    By Ionicon Analytik Ges.m.b.H.

  • Heterogeneous electro-Fenton oxidation of azo dye methyl orange catalyzed by magnetic Fe3O4 nanoparticles

    Azo dye methyl orange (MO) degradation by heterogeneous electro-Fenton (EF) with a magnetic nano-Fe3O4 catalyst was investigated. In this study, Fe3O4 was synthesized by a coprecipitation method and characterized by X-ray diffraction and scanning electron microscopy. The influences of the main operating parameters such as current density, pH, catalyst dosage and ...


    By IWA Publishing

  • Binary vs Quaternary Pumps

    How is a Gradient Created? Any liquid chromatograph is an amalgamation of a certain set of components that delivers to the scientist a monograph of the sample they are analyzing.  Traditionally, an LC system consists of a pump, an injector, a column heater, a detector and even more commonly these days a mass spectrometer or mass detector.  In ...


    By Waters Corporation

  • Pumping Ions – An Exercise in Engineering Sensitivity Into the Xevo TQ-XS Mass Spectrometer

    The challenge: Create the most sensitive mass spectrometer for quantitative analysis. That’s a tall order for any design engineering team. When given that assignment for a next-generation, tandem quadrupole mass spectrometer, our design engineers first spoke to those for whom analytical sensitivity means the most: scientists doing quantitative studies for ...


    By Waters Corporation

  • Facilitating Drug Discovery with HDX-Mass Spectrometry: Webinar Highlights

    Genetic Engineering and Biotechnology News and Waters recently conducted a webinar on how hydrogen deuterium exchange mass spectrometry (HDX-MS) can improve biotherapeutic drug discovery and development processes. Our first speaker, Prof. Ganesh Anand — a leading expert on HDX-MS at the National ...


    By Waters Corporation

  • High-throughput Microscale Bioanalysis is not a Paradox

    Question: When someone says microscale chromatography, what comes to mind? Increased sensitivity? Reduced sample volume? Enhanced MS sampling efficiency? Yes, yes, and yes! You might also say, “finicky,” “slow,” or “only one person in our group knows how to use it!” Maybe even, “there’s no way I can successfully transfer that method, so why ...


    By Waters Corporation

  • Tandem Quad Mass Spectrometry: The Foundation of Product Safety, Efficacy, and Decision-making

    There is a rightfully high expectation from consumers that the amounts of compounds and ingredients that producers report in their goods are accurate down to trace levels. Whether personally or professionally, we all rely on this analytical information coming from laboratories that enables critical decisions to be made. Analytical chemists have been performing quantitative studies for ...


    By Waters Corporation

  • Simon Fraser University Opens Suite of Mass Spectrometers for Natural Products Discovery Research

    As a graduate student at the University of British Columbia, Dr. Roger Linington discovered his future life’s work serendipitously. While studying sponges, it became clear to him that one of the challenges in studying macroorganisms is their limited or slowly replenishing supply. To perform mechanism and mode-of-action studies, he needed a larger, more accessible source of ...


    By Waters Corporation

  • Mass Spectrometry Makes Cents for UC San Diego Clinical Laboratory

    “Fast is fine; but accuracy is everything.” The quote is attributed to the famous Wyatt Earp, a sharpshooter and lawman who, with help from his two brothers, sent three outlaws to their graves in the Gunfight at the O.K. Corral in Tombstone, Arizona in 1881. One hundred ...


    By Waters Corporation

  • What’s the big deal about ion mobility mass spectrometry?

    Ion mobility spectrometry (IMS) is a technique that differentiates ions based on their size, shape, charge, and mass. While often used in small, portable devices at airports and remote locations for rapidly detecting small molecules whose mobility is known (for example, certain narcotics and explosives) when coupled with liquid chromatography-mass spectrometry (LC/MS), IMS provides an orthogonal ...


    By Waters Corporation

  • Tof-HRMS: Rescuing low-exposure bioanalysis applications from chemical noise

    The drug development process requires pharmacokinetic (PK) analysis to be performed as part of safety and efficacy studies in both preclinical species and human subjects. For high-sensitivity bioanalysis, liquid chromatography (LC) coupled to a triple quadrupole mass spectrometer (LC-MS/MS) is considered the gold standard for quantification. However, for some low-exposure applications, ...


    By Waters Corporation

  • Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass Spectrometry

    Haptoglobin (Hp) binds free hemoglobin (Hb) dimers to prevent negative consequences of Hb circulation in the extracellular environment. Although both monomeric Hb and myoglobin (Mb) species also present potential risks, their interactions with Hp have not been extensively studied. Mb is homologous to both the α- and β-chains of Hb and shares many conserved Hb/Hp interface residues, yet ...

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