MedChemExpress - Model Alteplase -105857-23-6
Alteplase (Actilyse; Activase), a tissue plasminogen activator prepared by recombination, is a thrombolytic agent that play important roles in acute ischemic stroke, pulmonary embolism, acute myocardial infarction, and occluded catheters[1][2][3][4].MCE products for research use only. We do not sell to patients.
Alteplase
MCE China：Alteplase
Brand：MedChemExpress (MCE)
Cat. No.HY-108865
CAS：105857-23-6
Synonyms：Actilyse; Activase
Storage：Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Alteplase (Actilyse; Activase), a tissue plasminogen activator prepared by recombination, is a thrombolytic agent that play important roles in acute ischemic stroke, pulmonary embolism, acute myocardial infarction, and occluded catheters.
In Vitro：Alteplase ( 8.3 and 250 μg/mL, 12 h) shows a signifcant reduction in viability of human fetal retinal pigment epithelial (hfRPE cells)[4]. Alteplase (8.3 and 250 μg/mL, 0-6 h) signifcantly decreases the transepithelial resistance in a time-dependent manner and induces cell death in hfRPE cells[4]. Product Information This product contains L-arginine, phosphoric acid, polysorbate 80, etc. as auxiliary materials. It is suitable for the treatment of acute myocardial infarction, acute massive pulmonary embolism with unstable blood flow, and acute ischemic stroke. Instructions The solution can be prepared with sterile water or normal saline (1 mg/mL).
In Vivo：Alteplase (0.9-10 mg/kg, i.v., 20 to 40 minutes post ictus or 180 and 240 minutes post ictus) is beneficial when given early after stroke onset ([3].
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References：
[1]. J Bastecký, et al. [Actilyse (a recombinant tissue-type plasminogen activator] in the treatment of acute myocardial infarct. Comparison of the effects of Actilyse and streptokinase]. Vnitr Lek. 1994 May;40(5):293-8. [Content Brief]
[2]. Micieli G, et al. Safety and efficacy of alteplase in the treatment of acute ischemic stroke. Vasc Health Risk Manag. 2009;5(1):397-409. [Content Brief]
[3]. Orset C, et al. Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis. Stroke. 2016 May;47(5):1312-1318. [Content Brief]
[4]. Kimura S, et al. Cytotoxic effects of alteplase, a recombinant tissue plasminogen activator, on human retinal pigment epithelial cells. Jpn J Ophthalmol. 2021 Sep;65(5):731-739. [Content Brief]
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