MedChemExpress - Model Folinic acid calcium -1492-18-8
Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity[1].MCE products for research use only. We do not sell to patients.
Folinic acid calcium
MCE China：Folinic acid calcium
Brand：MedChemExpress (MCE)
Cat. No.HY-13664
CAS：1492-18-8
Synonyms：Leucovorin calcium; Calcium folinate
Purity：99.71%
Storage：4°C, sealed storage, away from moisture and light *The compound is unstable in solutions, freshly prepared is recommended.
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Folinic acid calcium (Leucovorin calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.
In Vitro：MTX alone induces a concentration-related increase in % micronucleated binucleated cells (MNBN) and % aberrant cells (Abs). There is a decrease in nuclear division index (NDI) with increase in MTX concentration. Similarly, the mitotic index (MI) also decreases in all concentrations of MTX tested. The addition of Folinic acid at 50 μg/ mL significantly reduces % MNBN (40-68%) and % Abs (36-77%). Inhibition is also seen at 5 μg/ mL Folinic acid (12 to 54% for MNBN and 20 to 61% for Abs) [1].
In Vivo：Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].
IC50 & Target：Human Endogenous Metabolite
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References：
[1]. Keshava C, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res. 1998 Feb 2;397(2):221-8. [Content Brief]
[2]. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44. [Content Brief]
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