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N-Nitrosodiethylamine

MCE China：N-Nitrosodiethylamine

Brand：MedChemExpress (MCE)

Cat. No.HY-N7434

CAS：55-18-5

Synonyms：Diethylnitrosamine; DEN

Purity：99.97%

Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：N-Nitrosodiethylamine (Diethylnitrosamine) is a potent hepatocarcinogenic dialkylnitrosoamine. N-Nitrosodiethylamine is mainly present in tobacco smoke, water, cheddar cheese, cured, fried meals and many alcoholic beverages. N-Nitrosodiethylamine is responsible for the changes in the nuclear enzymes associated with DNA repair/replication. N-Nitrosodiethylamine results in various tumors in all animal species. The main target organs are the nasal cavity, trachea, lung, esophagus and liver.

In Vivo：N-Nitrosodiethylamine can be used to create hepatocellular carcinoma models. In beagle dogs, after intravenous administration, the plasma concentration of N-Nitrosodiethylamine shows a biphasic decline, with an average distribution half-life of 19 minutes, an average elimination half-life of 73 minutes, an average total body clearance of 43.3 mL/min/kg, a steady-state distribution volume of 1.9 L/kg, and an average residence time of 45 minutes. The average bioavailability of the lowest oral dose reaches 93%[3]. .f12{ font-size: 12px; } .fwb{ font-weight: bold; } .lh22{ line-height: 22px;; } .lh23 { line-height: 23px; } .pl13{ padding-left: 13px;; } .part { margin-top: 18px; } .mold-first-tit { width: 100%; height: 44px; line-height: 44px; background: #F9F7FB; border-bottom: 1px solid #EBE4F6; padding-left: 16px; box-sizing: border-box; margin-bottom: 17px; } .mold-second-tit:before { content:""; width: 6px; height: 6px; display: inline-block; border-radius: 50%; background: rgba(255,102,0,0.4); margin-right: 12px; position: relative; top: -3px; } .lft-border { border-left: 1px dotted #EBE4F6; padding-right: 12px; margin-left: 3px; box-sizing: border-box; padding-bottom: 12px; } /* .part .dec:last-child { border-bottom: 0; } */ .dec { margin: 10px 15px 0; padding-bottom: 10px; border-bottom: 1px dashed #EBE4F6; } .btm-border { border-left: 1px dashed #EBE4F6; } .text-bg { margin-top: 10px; background: #FFFBF1; padding: 14px; border-bottom: 0; position: relative; } .text-note-bg { margin-top: 10px; background: #FFFDF7; padding: 12px; border-bottom: 0; position: relative; } .text-note { width: 51px; height: 20px; line-height: 20px; background: #FFE2AA; text-align: center; border-radius: 0 0 8px 0; position: absolute; top: 0; left: 0; } .text-note-dec { margin-top: 15px;; } Induction of Liver cancer[1][2] Background Cytochrome P450 enzyme activates nitrosamine metabolism as an active electrophilic agent, making it cytotoxic, mutagenic and carcinogenic[4]. Specific Mmodeling Methods Male Wistar strain albino rats• 150–180 g&bull ; 12 weeks oldAdministration: 0.01% NDEA through drinking water for 15 weeks• or 200 mg/kg • i.p. &bull ; single dose Note (1)The liver tissues were examined histologically at 1–3 weeks after the administration of NDEA.(2)The rats were sacrificed by decapitation following overnight fast. Modeling Indicators Decreased in the final body weight and y increased the relative liver weight.Molecular changes: Decreased in the activities of SOD, CAT, GPx, GR, G6PD and GSH. Correlated Product(s): / Opposite Product(s): /

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References：

[1]. Ramakrishnan G, et al. Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chem Biol Interact. 2006 Jun 10;161(2):104-14.  [Content Brief]

[2]. Bansal AK, et al. Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver. Chem Biol Interact. 2005 Oct 20;156(2-3):101-11.  [Content Brief]

[3]. Gombar CT, et al. Pharmacokinetics of N-nitrosodimethylamine in beagles. Cancer Res. 1987 Jan 15;47(2):343-7.  [Content Brief]

[4]. Verna L, et al. N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Ther. 1996;71(1-2):57-81.  [Content Brief]