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MedChemExpressModel Cephalosporin C zinc salt -59143-60-1

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Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM[1]. Cephalosporin C zinc salt also has moderate anti-orthopoxvirus activity[2].
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Cephalosporin C zinc salt

MCE China:Cephalosporin C zinc salt

Brand:MedChemExpress (MCE)

Cat. No.HY-B1299A

CAS:59143-60-1

Purity:99.13%

Storage:4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM. Cephalosporin C zinc salt also has moderate anti-orthopoxvirus activity.

In Vitro:Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 ± 0.1 μM, 200-fold more potent than Na+ salt form of Cephalosporin C (ICC50CC-Na = 213 ± 30 μM)[1].

IC50 & Target:β-lactam

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References:

[1]. Seamon KJ, et al. A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase. J Biomol Screen. 2015 Jul;20(6):801-9.  [Content Brief]

[2]. Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.  [Content Brief]

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