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MedChemExpress - Model L-Norvaline -6600-40-4
L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease[1][2].MCE products for research use only. We do not sell to patients.
L-Norvaline
MCE China：L-Norvaline
Brand：MedChemExpress (MCE)
Cat. No.HY-Y0399
CAS：6600-40-4
Synonyms：Norvaline
Purity：98.0%
Storage：Store at room temperature 3 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease.
In Vivo：L-Norvaline (250 mg/L, in drinking water for 2.5 months) reduces the amyloid-β deposition in the mouse hippocampus, reduces TNF-α expression, promotes the expression of PSD-95 protein, and ameliorates cognitive ability in 3 Tg-AD mouse models[1]. L-Norvaline (20 mg/kg, every 3 days for 8 weeks, ip) exhibits antioxidant and anti-hyperglycemic effects in rats HFD and STZ (HY-13753) induced hyperglycemia models[2].
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References：
[1]. Polis B, et al., L-Norvaline, a new therapeutic agent against Alzheimer's disease. Neural Regen Res. 2019 Sep;14(9):1562-1572. [Content Brief]
[2]. Javrushyan H, et al., Antihyperglycemic activity of L-norvaline and L-arginine in high-fat diet and streptozotocin-treated male rats. Exp Mol Pathol. 2022 Jun;126:104763. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。