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MedChemExpress - Model L-Lactic acid -79-33-4
L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid has antiproliferative activity[1][2][3].MCE products for research use only. We do not sell to patients.
L-Lactic acid
MCE China：L-Lactic acid
Brand：MedChemExpress (MCE)
Cat. No.HY-Y0479
CAS：79-33-4
Synonyms：(S)-2-Hydroxypropanoic acid
Purity：98.0%
Storage：4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：L-Lactic acid is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid has antiproliferative activity.
In Vitro：L-Lactic Acid (24-48 h) secreted from gastric mucosal cells enhances growth of Helicobacter pylori[1]. L-Lactic Acid (48 h) shows antiproliferative activity against human A549 and MRC5 cells, with IC50 of 26.6 μM and 23.93 μM[2].
In Vivo：L-Lactic acid (25-50 mg/kg, i.p., twice, 4 days apart) dose-dependently enhances swimming endurance in mice[3].
IC50 & Target：Microbial Metabolite Human Endogenous Metabolite
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References：
[1]. 1. Takahashi T, et al. L-lactic acid secreted from gastric mucosal cells enhances growth of Helicobacter pylori. Helicobacter. 2007 Oct;12(5):532-40. [Content Brief]
[2]. 2. Recio R, et al. Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification. Eur J Med Chem. 2017 Sep 29;138:644-660. [Content Brief]
[3]. 3. Zhang G, et al. L-lactic acid's improvement of swimming endurance in mice. Int J Sport Nutr Exerc Metab. 2009 Dec;19(6):673-84. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。