MedChemExpress - Model Xestospongin C -88903-69-9
Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells[1][2][3].MCE products for research use only. We do not sell to patients.
Xestospongin C
MCE China：Xestospongin C
Brand：MedChemExpress (MCE)
Cat. No.HY-103312
CAS：88903-69-9
Synonyms：(-)-Xestospongin C
Purity：99.0%
Storage：Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Xestospongin C ((-)-Xestospongin C) is a selective, reversible inositol 1,4,5-trisphosphate receptor (IP3R) inhibitor. Xestospongin C acts as an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump of internal stores. Xestospongin C blocks IP3-induced Ca2+ release from cerebellar microsomes with an IC50 of 358 nM. Xestospongin C is a valuable tool for investigating the structure and function of IP3Rs and Ca2+ signaling in neuronal and nonneuronal cells.
In Vitro：Xestospongin C (XeC; 10 μM; 1 h before Aβ) pretreatment before Aβ1-42 (20 μM; 24 hours) application displays a significant decrease in the early apoptotic rate (9.87%) compared to the Aβ alone treated group (18.38%)[1]. Xestospongin C (10 μM; 1 h before Aβ) and Aβ1-42 (20 μM; 100 s) has significant main effects on the peak value and average values of Ca2+ changes, as well as a significant interaction in primary cultured hippocampal neurons[1].
In Vivo：Xestospongin C (3 μM; intracerebroventrical injection by a pump for four weeks) ameliorates the disinhibition-like behavior and long term spatial memory deficits of 8-month-old male APP/PS1 mice of Alzheimer's disease[1].
IC50 & Target：IP3R
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References：
[1]. Wang ZJ, et al. Xestospongin C, a Reversible IP3 Receptor Antagonist, Alleviates the Cognitive and Pathological Impairments in APP/PS1 Mice of Alzheimer's Disease. J Alzheimers Dis. 2019;72(4):1217-1231. [Content Brief]
[2]. Gafni J, Munsch JA, Lam TH, Catlin MC, Costa LG, Molinski TF, Pessah IN. Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptor. Neuron. 1997 Sep;19(3):723-33. doi: 10.1016/s0896-6273(00)80384-0. PMID: 9331361. [Content Brief]
[3]. Castonguay A, et al. Xestospongin C is a potent inhibitor of SERCA at a vertebrate synapse. Cell Calcium. 2002;32(1):39-47. [Content Brief]
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