ADAMTS - Model ATS-13 -Activity Assay System

What is your testing algorithm for patients suspected of having thrombotic thrombocytopenic purpura (TTP)? ATS-13 Activity Assay provides protocols to quantitatively measure ADAMTS-13 protease activity and determine the presence of inhibitory antibodies to ADAMTS-13 in human plasma. ADAMTS-13 is the protease that cleaves von Willebrand Factor. Significant decreases or an absence of ADAMTS-13 activity can lead to the formation of ultra-large vWF fragments and trigger intravascular platelet aggregation and microthrombosis, causing the signs and symptoms of thrombotic thrombocytopenic purpura, TTP.