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MedChemExpress - Model Nepodin -3785-24-8
Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus[1].Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK[2].Nepodin (Musizin) has antidiabetic and antimalarial activities.MCE products for research use only. We do not sell to patients.
Nepodin
MCE China:Nepodin
Brand:MedChemExpress (MCE)
Cat. No.HY-N5018
CAS:3785-24-8
Synonyms:Musizin
Purity:99.71%
Storage:4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping:Room temperature in continental US; may vary elsewhere.
Description:Nepodin (Musizin) is a quinone oxidoreductase (PfNDH2) inhibitor isolate from Rumex crispus.Nepodin (Musizin) stimulates the translocation of GLUT4 to the plasma membrane by activation of AMPK.Nepodin (Musizin) has antidiabetic and antimalarial activities.
In Vitro:Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively[1].
In Vivo:Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner[2].
IC50 & Target:Plasmodium
Hot selling product:Venlafaxine (hydrochloride) | Tesofensine | DCVC | N-Succinimidyl-S-acetylthioacetate | Amoxicillin (sodium) | N,N-Dimethylacetamide | Ecdysone | (S)-(+)-N-3-Benzylnirvanol | CR-1-31-B | Lipoteichoic acid
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
References:
[1]. Lee KH, et al. Antimalarial activity of nepodin isolated from Rumex crispus. Arch Pharm Res. 2013 Apr;36(4):430-5. [Content Brief]
[2]. Ha BG, et al. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors. 2014 Jul-Aug;40(4):436-47. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。
