InSphero 3D InSight - Animal Liver Microtissues
3D InSight™ Animal Liver Microtissues. Delivering greater physiological relevance for investigative toxicology studies. Custom 3D InSight™ Animal Liver Microtissues are available only on request for research partners, who perform translational toxicology studies on a regular basis. We offer fully tested and highly standardized monkey, dog, and rat liver toxicology models produced using species-specific primary hepatocytes and non-parenchymal liver cells. Ideal for studying species-specific effects of liver function and toxicity these custom animal liver toxicology models can be delivered assay-ready to your lab, or used in tailored in vitro toxicology services.
- De-risk and improve the success rate of your animal studies by pre-testing in a species-specific in vitro model that reflects in vivo biology
- Perform chronic toxicity testing with long-term treatments in selected animal models with a culture lifetime that exceeds that of conventional 2D cell culture
- Gain physiological relevance with an in vitro model exhibiting polarization of hepatocytes, formation of bile canaliculi, and functional cytochrome P450 activity
Monkey
3D InSight™ Monkey Liver Microtissues are produced from primary cynomolgus hepatocytes and are available as monoculture or in co-culture with human Kupffer cells. This custom animal model is suitable for short- and long-term translational studies.
Dog
InSphero 3D InSight™ Dog Liver Microtissues are produced using primary beagle hepatocytes and are available as a monoculture or in co-culture with beagle Kupffer cells. This is an early release animal model, available to development partners only.
Rat
3D InSight™ Rat Liver Microtissues are produced using primary Sprague-Dawley hepatocytes and are available as a monoculture or in co-culture with Sprague-Dawley Kupffer cells. This custom animal model is suitable for short-term studies only.