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Bioporto - Model ABS 001-07 -Anti-APC-80-AAT Complexes, Neoepitope (Human) Mouse Monoclonal Antibody
Specificity; ABS 001-07 reacts strongly with APC-AAT complexes in ELISA. It can be used in sandwich ELISA in combination with a polyclonal anti-protein C antiserum. Note, that the conformational neoepitope expressed in the APC-AAT complex can also be expressed in APC coated directly onto a high-binding microtiter plate.
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- Cat. No.: ABS 001-07
- Immunogen: Recombinant human activated protein C
- Host: Mouse
- Positive Species Reactivity: Human
- Negative Species Reactivity: Not determined
- Isotype: IgGl/k
- Clone Number: PC 7
- Epitope Specificity : ABS 001-07 is specific for a conformation-dependent neoepitope that is expressed in activated protein C upon complex-formation with al-antitrypsin.
- Unit Size: 400 uL: Cat. No. ABS 001-07-04 1 ml_: Cat. No. ABS 001-07-11 mg/mL +/- 15%. See Certificate of Analysis for details.
- Purification: Protein-A/G purified, from culture supernatant
- Form: Liquid
- Solvent : 0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCI and 15 mM sodium azide
- Conjugation: Unconjugated BSA free
- Storage : 4-8°C without exposure to light. No precautions necessary during handling.
- Target: Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62kDa proenzyme is activated by thrombin and the active enzyme cleaves factor Va and Villa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55kDa and the normal concentrations in human plasma is approximately 1-3 ng/ml because of the very fast turnover, the proenzyme concentration is approximately 3 ug/ml. The activated protein C (APC) is inhibited by members of the serine protease inhibitor (serpin) family, of which al-antitrypsin (AAT) and protein C inhibitor (PCI) are the most important.