Bioporto - Model ABS 002-09 -Anti-Complement Component C1s Mouse Monoclonal Antibody

Specificity: ABS 002-09 reacts in ELISA when tested with activated C1s.

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Cat, No.: ABS 002-09
Immunogen: Cls proenzyme purified from human plasma
Host: Mouse
Positive Species Reactivity: Human
Negative Species Reactivity: Not determined
Isotype: IgGl/k
Gene ID: 716
Clone Number: 9
Epitope Specificity: Epitope differs from that of ABS 002-49.
Unit Size: 400 uL: Cat. No. ABS 002-09-04 1 ml_: Cat. No. ABS 002-09-11 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification: Protein-A/G purified, from culture supernatant
Form: Liquid
Solvent: 0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCI and 15 mM sodium azide
Conjugation: Unconjugated BSAfree
Storage: 4-8°C without exposure to light. No precautions necessary during handling.
Target: Cls proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and 1438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the CI complex (Clq, Clr, Cls) comprises of two Cls and two Clr molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2.

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