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lino Biotech AG
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lino-Biotech - Architecture Universal Chip Chip

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Our universal chip architecture can tackle various applications addressing major pain points in novel cell and gene therapy. Know-how of 10 years is embedded in chip coating & ability to structure active lines to serve as molecular lens on chip surface. 
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DNA sequencing
liquid handling
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  • One Chip Design.
  • Endless Opportunities

Our universal chip architecture can tackle various applications addressing major pain points in novel cell and gene therapy. Biological functionalization of a MoloChip can be easily achieved by DNA-directed immobilization with a set of well characterized DNA sequences.

Orthogonal nature of the DNA directed immobilization in combination with the provided single – or six channel flow chambers allows for various subset combinations of lino´s MoloChips.

The sensor chip production is our core know-how. We successfully built on the established lithography-based single sensor fabrication process, two further suitable industrially accepted fabrication methods are currently under development. We have established a partner network to develop the four major components (the Optomechanic, the sensor chip, the liquid handling, the data evaluation software), while the operating software is being programmed inhouse by lino Biotech´s employees.
1x Molochip

1 capture single stranded DNA (ssDNA) sequence* fabricated by dip-coating or flow chamber modification.
Launch 2022

6x Molochip

6 orthogonal capture ssDNA sequences fabricated by flow chamber modification or micro spotting.
Launch 2023

54x Molochip

54 orthogonal capture ssDNA sequences fabricated by micro spotting.

Launch 2024

*colors represent different chemical functionalities
Protein A/G Sensor Chips

Improve your assay performance with our Protein A/G Sensor Chips. Our backfilled Chips allow you to measure directly in complex samples.

Streptavidin Sensor Chips

lino Biotech´s Streptavidin Sensor Chips are perfect for immobilizing biotinylated ligands (e.g. proteins, antibodies, and more).

Biological molecules, including proteins and nucleic acids, can be biotinylated using established protocols and immobilized onto the Streptavidin biosensor surface for custom assay development. There are many biotinylated biomolecules commercially available.

More about our sensor chips, e.g. a schematric illustration of the reactive immersion lithography (RIL), which allows the creation of the biomolecular recognition structure of the mologram on a light-sensitive non-fouling graft copolymer layer, can be found in our publication.

For more answered questions regarding our products, visit our FAQ.

Our sensor chips are ready for you to be used or they can be functionalized according to our customers needs in a simple process using established conjugation techniques. Each sensor chip has 54 mologram structures which can be functionalized in various ways. Since every mologram has its own focal point, parallel label-free multiplexing can be achieved easily. In combination with a single or six-chanell fluidic chamber, different sensor chip formats can be implemented via simple combinatorics.