Aurora Biomed Inc.

- Ion Channel Screening Assays


Aurora Biomed provides a wide range of ion channel assays to quickly and accurately provide results for drug discovery and development research worldwide. A convenient, integrated ordering system facilitates rapid assessment and processing of globally standardized tests. Assays are performed manually by patch clamp or by Qpatch. Cold flux assays are also available for limited compounds or candidates that cannot be screened with manual-patch clamp, with a strong linear correlation (R=0.88) and consistently identical drug rank orders between the cold flux and patch clamp methods. This method relies on non-radioactive trace ions measured by Aurora’s high-throughput proprietary atomic absorbance-based Ion Channel Reader series: ICR 8000 and ICR 12000

Electrophysiological in vitro and in vivo studies required by the FDA are available on either stable cell lines, cells transiently expressing channels of interest, transformed Xenopus oocytes (2 electrodes voltage clamp), cardiac myocytes (freshly isolated from rat or guinea pig), or neurons differentiated from human iPS.

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