Sieman - Model AP-100 -Automated Online Special Biochemistry Analyzer

By integrating the M-online module and upgrading the optimization control software, Sieman Technologies has launched AP-100 Automated Online Special Biochemistry Analyzer, a biochemical analysis system for online sampling and control of feed concentration.

This software can On-line analysis and control of biochemical parameters：
Glucose
Glutamine
Lactate
Lysine
Methanol/Ethanol
Glycerin
Sucrose
Xylose
Glutamate
NH4+, K+, Na+, Ca++, pH, Osm

Reduce the manual operation of the fermentation process, and realize the fine control of fermentation and culture.

AP-100 Automated Online Special Biochemistry Analyzer Application Scope

1. Provide reliable and stable process analysis data for the development and production of recombinant proteins, and control the feeding concentration
2. Monitor nutrient depletion of the medium and accumulation of metabolic wastes during cell culture
3. Glucose metabolism rate was detected in adherent culture to indirectly reflect cell growth
4. Accurately control the timing of medium replacement to ensure the reproducibility of experimental results
5. Determine the key control points of the process

AP-100 Automated Online Special Biochemistry Analyzer Features

• It can collect biochemical (carbon and nitrogen source) parameters in the process of biological culture in near real time, so as to realize multi-perspective monitoring and analysis of the whole biological culture process
• The specificity of enzyme electrode method to the substrate ensures that it can be developed from laboratory research and development to large-scale cGMP manufacturing
• Fully closed sterile sampling system is still safe and reliable after thousands of times of verification
• A single instrument can sample four reactors at the same time
• The sampling probe is PG13.5 or ingold interface, suitable for various stainless steel, glass reactors and disposable reactors
• General 4-20mA analog signal output, can be connected to the local automation control system (such as DCS system)
• According to customer requirements, 1~5 projects can be selected to monitor at the same time
• LIS data acquisition and control software can be selected to realize various fed-material culture strategies such as constant concentration, stepwise concentration and time-phased concentration culture