Halo Labs - Model Aura PTx -Backgrounded Imaging (BMI) Technology
Aura PTx™ gets you to your best formulation faster! Backgrounded Imaging (BMI) technology to give you accurate count, size, and morphology information about particles in your sample. Couple that with Fluorescence Membrane Microscopy (FMM), which gives you definitive ID of protein aggregates and an easy way to monitor polysorbate degradation. And did we mention you could do all of this with just 5 µL of sample and get data for 96 samples in few hours, not days? Hundreds of conditions can be analyzed early on, allowing scientists to gain key insights into drug stability to reduce development risk and time to market.
Excipients like polysorbate are routinely added to protein formulations to improve stability. But what happens when the polysorbate itself starts degrading? Aura PTx is the first system that allows you to detect and quantitate protein aggregates and polysorbate degradation using Thioflavin T and BODIPY FL C16 staining. Determine biologic and polysorbate stability, respectively – in one experiment!
The number of formulations and stress conditions that must be tested can get overwhelming. Aura PTx overcomes these limitations for you. It only takes 1 minute to analyze a sample and it’s 96-well automated format is highly suited to a DoE approach. Screen through tons of formulations quickly, with replicates!
Knowing if your aggregates are protein or non-protein is key; however, morphological characteristics often don’t tell you the whole picture. FMM on Aura PTx tells you exactly what is protein and what is not, even in mixed particles. Know exactly what’s in your formulation to get to your best formulation.