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Gentronix - Bacterial Reverse Mutation Assays
FromGentronix Ltd
Bacterial reverse mutation assays performed as fluctuation tests in a reduced liquid microplate format and exploiting a colorimetric read-out. Both Ames MPF and Ames II produce data with strong concordance to the classical Ames test, but require considerably lower test item amounts. This makes them ideally suited to high-throughput screening projects.
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- Quick, cost effective, high quality results.
- Ames MPF:
- same strains as OECD 471
- Ames II:
- TA98 & TAmix covers G-C & A-T mutations
- Low compound requirement
- High-throughput capacity
- Ames MPF - Test strains TA98, TA100, TA1535, TA1537
- Ames II – Test Strains TA98, TAmix
- Metabolic activation Typically, induced rat liver S9, other sources available
- Study Duration < 3 Weeks
- Endpoint Mutagenicity
