BenchChem - Model B1419994 -Ethyl 3-amino-5-(3-chlorophenyl)thiophene-2-carboxylate
Ethyl 3-amino-5-(3-chlorophenyl)thiophene-2-carboxylate, also known as 3-amino-5-(3-chlorophenyl)thiophene-2-carboxylic acid ethyl ester, is a thiophene-based compound with a wide range of applications in the fields of science and technology. It is a versatile compound that can be used in various synthetic and medicinal applications. It is a precursor for various pharmaceuticals, dyes, and other compounds. It is also a useful intermediate in the synthesis of other compounds.
Synthesis and Structural Elucidation
A study by (Hromatka et al., 1974) detailed the synthesis of ethyl 3-amino-5-trifluormethylthiophene-2-carboxylate, closely related to the compound in question. The research confirmed the structures of these compounds using NMR spectroscopy.
Anticancer Potential
(Mohareb et al., 2016) explored the synthesis of novel thiophene derivatives, including variants similar to ethyl 3-amino-5-(3-chlorophenyl)thiophene-2-carboxylate, for their potential anticancer activity. The study revealed significant anti-proliferative effects against several cancer cell lines.
Synthetic Versatility
A paper by (Chavan et al., 2016) discussed the synthesis of poly substituted 3-aminothiophenes using a one-pot protocol. This research demonstrates the versatility of such compounds in synthetic chemistry.
Antimicrobial Applications
(Abu-Hashem et al., 2011) investigated bifunctional thiophene derivatives for their antimicrobial potential. They found that these compounds exhibited promising antimicrobial activities, suggesting potential applications in this field.
Dyeing Polyester Fibres
(Iyun et al., 2015) synthesized compounds similar to ethyl 3-amino-5-(3-chlorophenyl)thiophene-2-carboxylate for use as disperse dyes in dyeing polyester fibers. They reported good fastness ratings in dyed fabrics, indicating a potential application in the textile industry.