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BostonModel BOS-981 -Small Molecule Furin Inhibitor

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BOS-981 is a first-in-class, small molecule furin inhibitor with therapeutic potential in pulmonary diseases, including cystic fibrosis (CF), vascular diseases, and infectious diseases.

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  • Furin is one of nine members of the proprotein convertase (PC) family, which converts protein precursors into their active forms.
  • Endogenous host furin is utilized by a variety of bacteria and viruses to process their proteins and toxins, e.g., anthrax, influenza A H5N1 (bird flu), Dengue, Marburg, and Zika viruses.