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MedChemExpressModel Cyclooctyne-O-NHS ester -1425803-45-7

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Cyclooctyne-O-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Cyclooctyne-O-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Cyclooctyne-O-NHS ester

MCE China:Cyclooctyne-O-NHS ester

Brand:MedChemExpress (MCE)

Cat. No.HY-126517

CAS:1425803-45-7

Purity:98.0%

Storage:-20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:Cyclooctyne-O-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Cyclooctyne-O-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro:ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

IC50 & Target:Cleavable Linker

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References:

[1]. Tao Wang, et al. Design and synthesis of tumor-targeting theranostic drug conjugates for SPECT and PET imaging studies. Bioorg Chem. 2018 Feb;76:458-467.  [Content Brief]

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