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Distek, Inc.
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  5. Distek BIOne Single-Use Bioreactor - ...

Distek BIOne Single-Use Bioreactor - Cell Culture and Cell-Free Applications

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The BIOne Single-Use Bioreactor (SUB) by Distek is well suited for a variety of cell culture and cell-free applications including but not limited to the production of monoclonal antibodies in CHO, AAV and Lentiviral vectors in SF9 and HEK293, adherent and aggregate stem cells, and mRNA. The BIOne SUBs have been well characterized based on kLa, P/V, and tip speed, simplifying the tech transfer and scale up process. These customizable solutions are compatible with most bioprocessing controllers, making them easily adaptable to any lab. 
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CUSTOMIZABLE 
 
The BIOne SUB is designed for flexibility and customization. Every component above and below the headplate can be configured to address the specific requirements of a wide range of cell culture and cell-free applications.
 
READY-TO-USE 
 
The BIOne SUB, assembled in Distek’s ISO 7 cleanroom with USP Class VI materials, is pressure-tested, gamma sterilized, and ready-to use out of the box. It eliminates the need for cleaning, assembly, or autoclaving, minimizing contamination risk.
 
AGNOSTIC DESIGN 
 
With a range of motor adapters available, the BIOne Single-Use Bioreactor is compatible with many common bioprocessing controllers on the market. This allows for seamless and rapid integration into any bioprocessing laboratory.
 
DESIGNED WITH ADAPTABILITY IN MIND 
 
Discover our single-use bioreactor solution for cell culture and cell-free applications, specifically designed to handle a variety of needs. Key features include single or dual pitched blade impellers, flute or microsparger, along with the option for an integrated single-use pH probe. Enjoy the benefits of a non-invasive DO (polarographic or optical) port and optional optical pH port for easy integration. Our weldable TPE tubing comes in various sizes to suit your process requirements. Adaptable exhaust and inlet (sparge and overlay) filters allow for efficient oxygen transfer to the culture.
 
CELL CULTURE GROWTH PROFILE: BIOne SUB vs. CONTROL 
 
Growth profiles and titer were evaluated with a CHO cell line in a 17-day fed-batch process. Titer was quantified starting on Day 6. Similar growth and titer were observed in the BIOne and glass vessel control. Performance results indicate that the BIOne single-use bioreactor system is a suitable bench scale SUB for mammalian cell growth and recombinant protein production.