Ceolus - Microcrystalline Cellulose (MCC) Used as Compression Excipients
CEOLUS is a range of microscrystalline cellulose products used as compression excipients. Ceolus products facilitate powder or microgranule compression, even at low concentrations in excipients. They also prevent capping during the compression phase. CEOLUS has three types of powder grades : UF, KG and PH which comply with USP/NF, Ph.Eur and JP pharmacopeia. It also has a colloidal grade known as RC which complies with USP/NF and JPE pharmacopeia.
Various CEOLUS™ grades have the following characteristics in pharmaceutical formulations:
- Excellent compactibility due to high plastic deformation
- Favorable disintegration while keeping high compactibility
- Improvement in flow due to density and/or morphology
- Good mixing properties helping to prevent particle segregation
- Wide granulation range due to optimal water holding capacity
With their good compactibility, CEOLUS™ UF and KG facilitate formulation design and tabletting efficiency, particularly for high dose, small tablet, and low-compactibility drug formulations.
CEOLUS™ PH grades are the most commonly used grades for oral solid dosage forms. They show excellent performance when used in granulation and direct compression of tablets.
CEOLUS™ RC, the colloidal grade composed of MCC.
They are various CEOLUS grades that have the following CEOLUS™ products that differ in density or angle of repose, characterizing compactibility and flowability properties formulation :
UF, KG and PH grades conform to the current USP/NF, Ph.Eur et JP. RC grade conforms to the current USP/NF and JPE.
CEOLUS™ is manufactured following the current excipient Good Manufacturing Practices (GMPs).
The regulatory and quality package is available on request.