MedChemExpress - Model Dimercaprol -59-52-9
Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning[1].MCE products for research use only. We do not sell to patients.
Dimercaprol
MCE China：Dimercaprol
Brand：MedChemExpress (MCE)
Cat. No.HY-B1285
CAS：59-52-9
Synonyms：2,3-Dimercapto-1-propanol; Dithioglycerol
Purity：98.0%
Storage：4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning.
In Vitro：Dimercaprol (10-100 μM; 4 h) could significantly protect PC-12 cells from Acrolein-mediated cell death in a dose-dependent manner[2].
In Vivo：Dimercaprol (2,3-Dimercapto-1-propanol; 12.5-75 mg/kg; subcutaneous injection; once) increases the death percentage and decreases the mercury contents in liver and kidney[3].
IC50 & Target：HIV[1] Cellular Effect Cell Line Type Value Description References
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References：
[1]. Kubota S, et al. 2,3 Dimercapto-1-propanol inhibits HIV-1 tat activity, viral production, and infectivity in vitro. AIDS Res Hum Retroviruses. 1990 Jul;6(7):919-27. [Content Brief]
[2]. Ran Tian, et al. Dimercaprol is an acrolein scavenger that mitigates acrolein-mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury. J Neurochem. 2017 Jun;141(5):708-720. [Content Brief]
[3]. Taciane Roza, et al. 2,3-Dimercapto-1-propanol does not alter the porphobilinogen synthase inhibition but decreases the mercury content in liver and kidney of suckling rats exposed to HgCl2. Basic Clin Pharmacol Toxicol. 2005 Apr;96(4):302-8. [Content Brief]
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