MedChemExpress - Model Momordicoside G -81371-54-2
Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury[1].MCE products for research use only. We do not sell to patients.
Momordicoside G
MCE China：Momordicoside G
Brand：MedChemExpress (MCE)
Cat. No.HY-N3248
CAS：81371-54-2
Synonyms：Momordicacoside G
Storage：Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Momordicoside G (Momordicacoside G) is an orally active cucurbitane-type triterpene glycoside. Momordicoside G selectively induces apoptosis of M1-like macrophages, without affecting M2-like macrophages. Momordicoside G reduces intracellular ROS levels and promotes autophagy. Momordicoside G also has anticancer activity, inhibiting the growth of cancer cell lines. Momordicoside G stimulates M2-associated lung injury repair and prevents inflammatory lung cancer injury.
In Vitro：Raw264.7 macrophages is stimulated by 10 ng/mL LPS or 10 ng/mL IL-10 for 24 h to obtain M1-like (iNOS+) and M2-like (arginase+) macrophages[1]. Momordicoside G (10-40 μM; 24 h) inhibits the cell viability of M1 macrophages, but not M2 macrophage[1]. Momordicoside G (40 μM) induces M1 macrophage apoptosis in vitro, as well as decreasing the level of NO, and increasing the level of IL-12, IL-10, and TGF-β[1].
In Vivo：Lung carcinogenic model in ICR mice is induced by Urethane (HY-B1207) (600 mg/kg; i.p.; once weekly for 4 or 8 weeks), or in in macrophage-competent and macrophage-deleted mice is induced by LPS (HY-D1056) (2 mg/kg; intratracheal method) with 4 mg/mouse IEC (i.p.)[1]. Momordicoside G (50 mg/kg; p.o.; once daily for 4 or 8 weeks) prevents urethane-induced lung injury and carcinoma lesions in mouse lung carcinogenic model[1]. Momordicoside G (50 mg/kg; p.o.; once daily for 2 weeks) promotes lung injury repair in LPS-induced lung injury model[1].
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References：
[1]. Du Z, et al. Momordicoside G Regulates Macrophage Phenotypes to Stimulate Efficient Repair of Lung Injury and Prevent Urethane-Induced Lung Carcinoma Lesions. Front Pharmacol. 2019 Mar 29;10:321. [Content Brief]
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