DynaPro - Model II -Plate Reader
Revolutionize your performance by replacing your conventional, cuvette-based dynamic light scattering unit with the automated DynaPro Plate Reader III. The DynaPro excels at high-throughput sizing and screening of pharmaceutical and nanoparticle formulations to enable novel workflows that simply would not be possible with other DLS instruments. Even if you need to run just a handful of samples, it`s a great productivity booster.
For biotherapeutic development, the DynaPro Plate Reader is a comprehensive solution for stability evaluation. Measure aggregation, aggregate size distributions, changes in solution molecular weight, and propensity for aggregation: indicators of both thermal stability (Tonset, Tm, Tagg) and colloidal stability (A2/B22, kD) may be quantified with plate-based DLS and SLS. Even viscosity of concentrated protein solutions can be screened across dozens of formulations in a single plate.
Compatible with DYNAMICSThe DynaPro Plate Reader is operated by DYNAMICS, our powerful software package for collecting, analyzing, and reporting automated batch dynamic and static light scattering data.
DYNAMICS is offered with a 21 CFR Part 11 compliant Security Pack option, enabling the use of the DynaPro Plate Reader in a GMP environment.
The DynaPro Plate Reader II offers dynamic light scattering (DLS) measurements of the size and interactions of proteins, nanoparticles and other macromolecules in situ in industry-standard microwell plates. No liquid handling occurs after dispensing into the plates, to maximize throughput and minimize sample carryover. This ground-breaking instrument provides rapid optimization of the formulation process for:
- Biotherapeutics such as monoclonal antibodies and virus-like particles (VLPs)
- Nanoparticle drug delivery vehicles including liposomes and conjugated gold NPs
- Polymer-encapsulated drug particles
Key features
- Measure hydrodynamic radius from 0.5 nm to 1000 nm
- Sensitivity down to 0.125 mg/mL lysozyme
- Industry standard microwell plates of 96, 384 or 1536 wells
- All measurements made in situ in the wells
- Temperature ramps from 4°C to 85°C
- Integrates with plate-based liquid handling robotics
A wealth of applications
The DynaPro Plate Reader II provides unparalleled levels of ease-of-use, productivity, reproducibility, and flexibility in order to address additional demanding applications such as:
- Optimizing protein crystallization
- Assessing aggregation or oligomerization
- Determining protein stability-indicating parameters such as thermal denaturation and colloidal stability
- Screening high-concentration protein solutions for reversible association and viscosity
- Rapid or slow temperature ramps 4°C - 85°C with excellent uniformity across the plates. Samples are heated in parallel and all filled wells measured at each temperature
- Well read times as short as 5-10 seconds
- Integration with liquid-handling robots for higher levels of automation, especially when your workflow is plate-based, and utilizes spectroscopic and other plate readers in addition to DLS
- A camera for viewing each well from below, to aid in data diagnostics (e.g. to detect precipitation or bubble formation)
- Lab automation
An OLE software API is available for interfacing the DynaPro Plate Reader II to robotic liquid handling in the high-throughput lab. This capability allows for fully automated plate loading and data collection.
Wyatt partners with several companies that offer integrated solutions for automated loading and analysis of plated samples: