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MedChemExpress - Model Cucurbitacin D -3877-86-9
Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects[1][2][3][4].MCE products for research use only. We do not sell to patients.
Cucurbitacin D
MCE China：Cucurbitacin D
Brand：MedChemExpress (MCE)
Cat. No.HY-N1986
CAS：3877-86-9
Purity：98.41%
Storage：4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Cucurbitacin D is the active ingredient in Trichosanthes kirilowii and can disrupt the interaction between Hsp90 and two co-chaperones, Cdc37 and p23. Cucurbitacin D is an inflammasome activator. Cucurbitacin D induces cell cycle arrest and cell apoptosis, exhibiting anti-tumor and anti-inflammatory effects.
In Vitro：Cucurbitacin D (0.5 μg/mL, 24 h) combined with doxorubicin can induce apoptosis in MCF7/ADR cells and cause G2/M cell cycle arrest[1]. Cucurbitacin D (0.125-16 μg/mL, 24-72 h) significantly inhibits the growth of MCF7 and MCF7/ADR cells in a dose- and time-dependent manner[1]. Cucurbitacin D (0.5-2 μg/mL, 24 h) inhibits STAT3 signaling in MCF7/ADR cells and suppresses the NF-κB signaling pathway[1]. Cucurbitacin D enhances the production of IL-1β in LPS (HY-D1056) induced THP-1, PECs, BMDMs, and RAW264 cells[2].
In Vivo：Cucurbitacin D (1 mg/kg, intratumoral injection, three times a week for four weeks) inhibits tumor proliferation in mice[3].
IC50 & Target：HSP90
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References：
[1]. Jin Mo Ku, et al. Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells. Mol Cell Biochem. 2015 Nov;409(1-2):33-43. [Content Brief]
[2]. Yuan Song, et al. Cucurbitacin D is a new inflammasome activator in macrophages. Int Immunopharmacol. 2013 Dec;17(4):1044-50. [Content Brief]
[3]. Mohammed Sikander, et al. Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer. Sci Rep. 2016 Nov 8:6:36594. [Content Brief]
[4]. Hall JA, et al. Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery. J Nat Prod. 2015 Apr 24;78(4):873-9. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world；
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas；
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects；
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services；
• It has a professional experimental center and strict quality control and verification system；
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products；
• The biological activity of the products has been verified by the experiments of customers in various countries；
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers；
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world；
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。