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Proteros - Extensive Biophysics Platform
At Proteros we have built an extensive biophysics platform that enables you to generate the target-ligand interaction results and insight that you need and allow you to REACH RIGHT FASTER.
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Our Biophysics platforms enable:
- Biophysical assays for target-ligand interaction analysis
- Library screening (incl fragments)
- Quantification of binding affinity and/or kinetics: Kd, kon, koff, kinact, ?S, ?H, ?G
- Orthogonal hit verification
- Site of ligand binding
NANODSF
- Technology: PrometheusTM (NanoTemper technologies) (label free)
- Deliverable: TmApplications: Primary Screen (incl. fragments), orthogonal screen, allosteric screen, testing of protein stability, construct evaluation, investigation of protein domain structure
- Throughput: Screen: up to 1,500 ligands/week
TSA
- Technology: Thermoshift assays (based on dyes)
- Deliverable: Tm
- Applications: Primary Screen (incl. fragments), orthogonal screen, allosteric screen, testing of protein stability, construct evaluation, investigation of protein domain structure
- Throughput: Screen: up to 20,000 ligands/week
Microscalethermophor (MST)
- Technology: Monolith NT115picoTm (NanoTem technologies)
- Deliverable: KdApplications: Primary screen (in-fragments), hit profiling, lead optimizationThroughput:
- Screen: up to 1,500 ligands/week, Kd: up to 50 ligands/week