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MedChemExpress - Model 8-Bromoadenine -6974-78-3
8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium[1][2].MCE products for research use only. We do not sell to patients.
8-Bromoadenine
MCE China:8-Bromoadenine
Brand:MedChemExpress (MCE)
Cat. No.HY-W076740
CAS:6974-78-3
Synonyms:8-Bromo-9H-purin-6-amine
Purity:98.92%
Storage:4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Shipping:Room temperature in continental US; may vary elsewhere.
Description:8-Bromoadenine (8-Bromo-9H-purin-6-amine) is a DNA radiosensitizer that inhibits DNA single-strand break repair in cells. 8-Bromoadenine is a brominated derivative of adenine, and radioactive adenine can be prepared by replacing bromine with deuterium.
In Vitro:8-Bromoadenine (0.1 mM; 30-90 min) inhibits DNA single-strand break repair in HeLa-M cell monolayer cultures. And after γ irradiation, the quality of DNA synthesized by cells is lower than that of DNA synthesized by cells without purine addition[1].
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References:
[1]. Tkalich A V, et al. Effect of 8-bromoadenine on DNA repair[J]. Tsitologiia, 1980, 22(8): 994-997.
[2]. Radioactively marked nucleic acid units. German Democratic Republic, DD106383 A1 1974-06-12.
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。
