Gentronix - Micronucleus Assay 96-Well + FISH

A miniaturised version of a TK6 in vitro micronucleus test in which 2 treatment conditions are utilised in a 96-well microplate format. Micronucleus formation is assessed in 2000 mononuclear cells by microscopy, producing a highly predictive screen of the regulatory OECD 487 endpoint from minimal test item.The study can also be designed to enable incorporation of FISH pan-centromeric staining techniques, to enable additional assessment of micronuclei for presence/absence of centromeres, giving a prediction of whether a material is predominately aneugenic or clastogenic.