PicoKine - Human HEXA ELISA Kit

Product Name

Human HEXA ELISA Kit PicoKine®

View all Hexosaminidase A/HEXA ELISA kits

SKU/Catalog Number

EK2215

Size

96 wells/kit, with removable strips.

*Question: How many samples can I assay/run in this kit? 

Description

Human HEXA Kit PicoKine™ (96 Tests). Quantitate Human HEXA in bone tissue, cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 50 pg/ml.

Storage & Handling

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Cite This Product

Human HEXA ELISA Kit PicoKine® (Boster Biological Technology, Pleasanton CA, USA, Catalog # EK2215)

Clonality Of Antibodies

See  Datasheet for details

Immunogen

Expression system for standard: NS0; Immunogen sequence: M1-T529

Sensitivity

<50 pg/ml

Assay Range

312 pg/ml - 20,000 pg/ml

Cross-Reactivity

There is no detectable cross-reactivity with other relevant proteins.

Reactive Species

EK2215 is reactive to HEXA in Human samples

Validated Sample Types

bone tissue, cell culture supernatants, serum and plasma (heparin, EDTA)

Application Guarantee

EK2215 is guaranteed for ELISA in Human by Boster Guarantee

See how Boster Bio validate our ELISA kits: ELISA Validation Information

Background Of Hexosaminidase A/HEXA

Hexosaminidase A (alpha polypeptide), also known as HEXA, is an enzyme that in humans is encoded by the HEXA gene, located on the 15th chromosome. This gene encodes a member of the glycosyl hydrolase 20 family of proteins. The encoded preproprotein is proteolytically processed to generate the alpha subunit of the lysosomal enzyme beta-hexosaminidase. This enzyme, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene lead to an accumulation of GM2 ganglioside in neurons, the underlying cause of neurodegenerative disorders termed the GM2 gangliosidoses, including Tay-Sachs disease (GM2-gangliosidosis type I). Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.