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Luxembourg Bio Technologies
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  5. Model HOBt Hydrate - ...

Model HOBt Hydrate -Hydroxybenzotriazole Hydrate

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N-Hydroxybenzotriazole, developed by W. König and R. Geiger in 1970 was the most popular additive during the last decades. CAS: 123333-53-9. Synonym: Hydroxybenzotriazole

 

Purity
≥99.0%

Molecular Formula
C6H5N3O•H2O

Molecular Weight
135.12 [gr/mol]

Appearance
White to off-white crystalline powder

Storage Conditions
Store in a cool and dry place

  • HOBt is one of the most effective suppressors of racemization in carbodiimide-mediated reactions.
  • The most important drawback of the additive lies in its explosive character, especially in water-free form. Therefore, its availability is more restricted today but it can be substituted by more stable additives as OxymaPure and K-Oxyma.
  • Polymer-bound HOBt is used for the formation of medium ring lactams with DCC in the presence of resin-bound esters and also for amides synthesis.