Ronner - Industrial-Grade Preparative Liquid Chromatography System
HPPLC is certainly one of the most powerful purification techniques available today, and as such must be considered by process and production engineers with the same attention as distillation, crystallization and other more traditional techniques.
Provided it is properly used, HPPLC can be cheaper than traditional techniques, provide higher yields, higher degrees of purity and save on purification times, a particularly critical aspect in the highly competitive world of the modern pharmaceutical industry. Properly using HPPLC means understanding the behaviour of columns under highly overloaded conditions and using such beneficial effects as displacement effects. It also means using the right packing material, the right column efficiency and the appropriate column technology, as well as considering alternative strategies such as shave-recycling, backflush, SMB, etc. SMB is of particular interest for binary separations (but not only) and in the near future is expected to become the technique of choice for such separations at large and very large scales.
CBD purification is based on reverse-phase liquid chromatography. This technique is based on the proven plant extraction and purification technologies in industrial areas.
HPLC method has the advantages of high pressure, reliable performance, safety, and low maintenance cost. The production cost and the purity of the final chemical are all controlled.
Compare with other methods, the solvent and packing material costs in HPLC can reduce over 50%.
For pharmaceutical-grade CBD powders, the HPLC purification method is the best choice. Combine with recrystallization, you can get 99%-99.9% CBD powder.