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Comi Polaris - Model HT/GMP -Inverting Filter Centrifuge for API, Pharmaceutical, and Chemical Processes
FromComi Polaris
The Inverting Filter Centrifuge is engineered to address the demanding requirements of solid-liquid separation in API production, pharmaceutical, and fine chemical industries. This centrifuge is distinguished by its ability to isolate and wash active pharmaceutical ingredients within a secure, closed environment, thus preventing residual material from adhering. Its design optimizes the separation process, effectively removing solids from liquids and incorporating a built-in washing phase to enhance the purity and quality of APIs. By mechanically reducing the liquid content, it minimizes downstream processing requirements. The production cycle involves a series of steps: feeding suspension into the centrifuge, efficient cake washing through turbulence-induced distribution, enhanced deliquoring using centrifugal and hyperbaric systems, and final solid discharge. The centrifuge's clean-in-place system, augmented by washing machine effect and spray ball cleaning, ensures comprehensive maintenance of hygiene standards. This centrifuge embodies reliable, efficient, and safe separation technology.Most popular related searches
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Inverting Filter Centrifuge: A Versatile Solution for API, Pharmaceutical, and Chemical Processes
The Inverting Filter Centrifuge is specifically designed to optimize challenging solid-liquid separation processes within API (active pharmaceutical ingredient), pharmaceutical, and fine chemical industries. Now an industry standard, and known for its reliability and advanced design, the inverting centrifuge provides efficient isolation and washing of APIs in a safe, enclosed environment, ensuring no residual heel remains.
Why Use Inverting Filter Centrifuges for API Filtration?
When producing APIs in reactors or crystallizers, isolating the API from the other parts of the slurry through filtration is critical. The Inverting Filter Centrifuge is ideal for efficiently separating solids from liquids, with a built-in washing step that enhances API purity. By reducing liquid content mechanically, this centrifuge also lowers downstream processing needs, protecting the API’s quality.
Benefits of the Inverting Filter Centrifuge in Challenging Applications
For products that are sticky, compressible, or have low moisture content requirements, the inverting centrifuge offers a solution that traditional designs cannot. The filter cloth inverts to push the filter cake out of the horizontally rotating drum, leaving no residual material behind. It also protects the product by minimizing crystal destruction. Therefore, the centrifuge’s unique construction maximizes recovery and purity, even for the most complex materials.
- Pharmaceutical and fine chemical products
- Active Pharmaceutical Ingredients (APIs)
- Pharmaceutical intermediate products
- High Potent Active Products (HPAPI)
- Pharmaceutical synthesis products
- Ideal for slow filtering and compressible products
- High separation efficiency for products with fine particles, compressible products (low filterability), and fine chemical/API (Active Pharmaceutical Ingredients)
- No residual heel
- Gentle product discharge
- Hyper centrifugation available for fixed bed drying
- 100% access to solids and filtrate housing
- No contact between the operator and product during operation makes it ideal for the production of pharmaceutical synthesis products
- Sizes range from 300mm (11.8 in.) diameter to 1000mm (39.4 in.) diameter – See charts below
- Inertia pad with dampers allows installation directly on the floor
- Through-the-wall installation for clean rooms
- Even cake distribution due to the horizontal design
- Gently handles crystals: the solids discharge is achieved by means of filter cloth inversion (reversible bag), allowing soft crystals to be recovered without breaking
- Electromechanical filter cloth inversion (oil-free execution)
- The short discharge time and complete elimination of the heel cake at every cycle result in high yield. Ultra-thin cakes can be processed efficiently. Even products with low filtering properties (those with fine particles and high compressibility) can be separated, resulting in uniform cake washing.
- Various levels of containment options are available for solids discharge
- Complete PLC controls with touch-screen interface
- Switch between automatic and manual operation
- Variable frequency drive (VRD) speed control
- ATEX (Europe) electrical enclosures or NEC (North America)
- Optional instrumentation integrated into the control system including oxygen monitoring, temperature, pressure, liquid feed flow, and N2 purge
- Its highly effective C.I.P. system (Clean-in- Place) uses a W.M.E. (Washing Machine Effect) and spray balls
- Removal of bound moisture is achieved by dry or heated gas at up to 6 barg differential pressure across the cake (Hyperbaric Centrifugation System – HCS)
- The front casing can be fully opened, allowing the process area to be completely inspected
- Cake volumes from 7 (pilot unit) to 210 liters – See charts below
- High G factors from 1018 to 1663 (pilot unit) – See charts below
- Basket load setting via load cell system
- Filter cloths available in polypropylene, HALAR, or PTFE
- Gas tightness at 400 mm H2O
- High surface finishes
- Complete FDA validation documentation
- Construction materials
- Parts in contact with the product: all stainless steels and special alloys are available, such as AISI 316L, AISI 904L, hastelloy, monel, alloy 59, 254 SMO, nickel, titanium, and SAF 2205
- Surface coating option: Halar (ECTFE)
- Elastomers: antistatic and FDA certified, Teflon ETFE, and hard rubber