MedChemExpress - Model Thalidomide 4-fluoride -835616-60-9
Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966)[1].MCE products for research use only. We do not sell to patients.
Thalidomide 4-fluoride
MCE China：Thalidomide 4-fluoride
Brand：MedChemExpress (MCE)
Cat. No.HY-41547
CAS：835616-60-9
Synonyms：Cereblon ligand 4; E3 ligase Ligand 4
Purity：99.65%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).
In Vitro：Thalidomide targets cereblon (CRBN), a ubiquitously expressed protein that is part of the cullin-4 E3 ubiquitin ligase complex, CUL4-RBX1-DDB1 (CRL4). Cereblon mediates the ubiquitination and subsequent proteasomal degradation of target proteins[2].
IC50 & Target：Cereblon
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References：
[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.
[2]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief]
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