KrosFlo - Model FS -Fully Automate Flat Sheet TFF Systems

Modular, plug-and-play hardware with diaphragm pump 

The KrosFlo^® FS Systems achieve an unparalleled combination of configurability and automation and compliance for flat sheet TFF processes.  All components, either directly or indirectly, connect to the main KrosFlo^® FS diaphragm pump, which then communicates with the KF Comm 2 software for control and monitoring.

• Configure a minimal number of components for simple applications such as concentration (C) or diafiltration (D)
• Plug-and-play additional components for fractionation (F) and multi-step processes (i.e. CDC/D/C)

Configurable ProConnex® Flow Paths
Enhanced through an engineering design process, ProConnex® Flow Paths are customized, configurable and complete assemblies for tangential flow filtration.  Designed for use with hollow fiber and/or flat sheet TFF systems, the assemblies are sterile, fit for upstream or downstream processing and manufactured in compliance with ISO guidelines in an ISO 7 clean room.

Transfer bi-directional data through proprietary board

An advanced microprocessor-based controller is integrated into the main KrosFlo^® FS System pumps, enabling plug-and-play hardware component behavior. Bi-directional communication is established between the KF Comm 2 software and hardware components, such as the Automatic Back Pressure Control Valve, scales, auxiliary pumps and the Konduit device.

Menu-driven Software for Optimized TFF
KF Comm 2 Software, backward compatible with legacy KrosFlo® KR2i and KrosFlo® KMPi Systems, is conveniently installed on any computer using the Windows Operating System. The software is compatible with Chrome, Mozilla, Firefox and Microsoft Explorer browsers and is always current with automatic software and firmware updates.

• Proprietary software optimized for KrosFlo® TFF Systems
• Validated for GMP Processes with optional 21 CFR Part 11 option
• Intuitive workflow with 13 modes of operation

Automatic Back Pressure Control Valve

A Repligen-exclusive technology, the Automatic Back Pressure Control Valve adds transmembrane pressure (TMP) control to every TFF process, reducing operator hands-on-time and improving process reproducibility. 

• Automatically adjust tubing pinch distance according to user-defined set-points
• Maintain uniform TMP throughout process run, decreasing membrane fouling
• Control permeate pressure and flow during microfiltration applications
• Use with compatible tubing sizes 13, 14, 16, 25, HP15, 17, HP24, 18, HP35, 36, and HP36
• Activate automatically using inlet, retentate, permeate or transmembrane pressures