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LabLogic BetaModel RAM 6 -Radio-HPLC Flow Detector

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The world’s leading radio flow detector for HPLC offers unrivalled sensitivity, resolution and versatility. Used by thousands of researchers worldwide, the Beta-RAM has positioned itself as the leading radio flow detector for HPLC in radiolabelled studies. Coupled with our radiochromatography software, Laura, it provides comprehensive data collection and analysis for ADME and eFate research, as well as radiochemical purity checks. The Beta-RAM 6 is now available in two options: the IRIS and the SC (Standard Cell).

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The IRIS model offers the user a wide range of cell volumes, all available without having to change the flow cell.

IRIS Technology

IRIS technology allows users to optimise sensitivity and resolution by creating a range of cell volumes available dynamically. The IRIS aperture opens and closes to reveal or obscure the flow cell tubing. Closing the IRIS replicates a smaller cell volume delivering sharper peaks and improved resolution. Opening the IRIS will replicate a larger cell with a longer residence time for improved sensitivity.

Integrated Liquid Manifold

The compact and integrated liquid manifold handles the liquid distribution and mixing with scintillation cocktail. The manifold is designed to reduce dead volume to the minimum, ensuring excellent peak shape and resolution.

The IRIS model offers the user a wide range of cell volumes, all available without having to change the flow cell.

IRIS Technology

IRIS technology allows users to optimise sensitivity and resolution by creating a range of cell volumes available dynamically. The IRIS aperture opens and closes to reveal or obscure the flow cell tubing. Closing the IRIS replicates a smaller cell volume delivering sharper peaks and improved resolution. Opening the IRIS will replicate a larger cell with a longer residence time for improved sensitivity.

Integrated Liquid Manifold

The compact and integrated liquid manifold handles the liquid distribution and mixing with scintillation cocktail. The manifold is designed to reduce dead volume to the minimum, ensuring excellent peak shape and resolution.

SC Features

For users that require a traditional flow cell configuration, the Standard Cell (SC) provides the option of using either liquid mixing or solid scintillator cells.

Replaceable Flow Cells

Flow cells can be changed easily and are available in a range of volumes and types, including fixed volume solid scintillator and liquid mixing cells.

Horizontal or Vertical Operation

The standard cell model can be operated horizontally, as a standalone unit, or as part of an HPLC stack. It can also be placed in a space-saving vertical position alongside the HPLC.

For users that require a traditional flow cell configuration, the Standard Cell (SC) provides the option of using either liquid mixing or solid scintillator cells.

Replaceable Flow Cells

Flow cells can be changed easily and are available in a range of volumes and types, including fixed volume solid scintillator and liquid mixing cells.

Horizontal or Vertical Operation

The standard cell model can be operated horizontally, as a stand-alone unit, or as part of an HPLC stack. It can also be placed in a space-saving vertical position alongside the HPLC.

*Applicable to both Beta-RAM 6 Models

Accurate Built-In Liquid Mixing

The Beta-RAM has a built-in scintillation cocktail pump, accurately controlled by Laura software, plus a low-dead-volume mixing tee to provide the very best conditions for sensitive counting of even low-energy beta emitters such as ³H.

Active Counting Mode

Active Counting Mode allows the system to monitor and adjust run conditions in real-time, dynamically applying the most appropriate settings. This gives on-line detection limits previously only achieved off-line, as well as improved resolution and peak definition.

Radwaste

The Radwaste valve diverts the outflow to a separate waste line when counts of radioactivity are detected. Simply select the count threshold in Laura, and when this is met, the waste flow will switch from cold to hot. This can be collected in a separate container reducing the amount of contaminated waste produced.

Mass Spec Compatibility

A non-return valve is available for users that wish to use the system in tandem with a mass spectrometer.

Stop Flow

The stop flow mode allows the user to achieve superb levels of sensitivity previously unavailable with on-line counting methods. By controlling both the Beta-RAM and HPLC system, the user can define a fraction time and counting time therefore eliminating the labour intensive, time consuming process of fraction collecting.

Cell ID

All parameters relative to flow cell type and serial number are seamlessly identified in the Laura software. Cell ID allows for automatic calculation of eluate residence time and other counting units such as CPM and DPM.

Support for UHPLC, Rapid Resolution LC, Fast LC

The latest liquid chromatography technologies require dead volumes, connections and flow control of the scintillation cocktail to be finely managed. The parameters on the Model 6 are optimised to give superb performance with even the most rigorous LC demands.

Reliability

With over 30 years of development and used by thousands of researchers worldwide the Beta-RAM, coupled with the industry standard Laura software, continues to lead the way for radiochromatographers.

Stackable Radio-HPLC Detector

The Beta-RAM can be easily stacked with HPLC systems; specifically, it has been designed to integrate with LabLogic`s Logi-CHROM HPLC stack.