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Proteros - Library Screening
High-quality library collections offered by Proteros in collaboration with Enamine for immediate screening and seamless post-screening processes.
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- PAINS-free screening libraries [no pan-assay interference compounds] designed by deselection of reactive compounds and unfavorable physicochemical properties
- All libraries Ro3 or Ro5 compliant
- Proteros hand-selected compounds/fragments from Enamine
- Hit expansion into full-range of available Enamine compounds
- Fast synthesis of hit analogues at Enamine (building blocks available)
- Easy and cost-efficient access to high quality screening libraries
- Rapid transition into Proteros structural biology platform
- Fast HTS follow up using:
- Reporter Displacement Assay (RDA)
- Enzymatic Assays
- TSA
- SPR
- MST
- nanoDSF
- nanoBRET
FRAGMENT LIBRARY
3k Proteros hand-selected fragments
- Ro3 compliant, MW 160- 300 g/mol, solubility checked
- High diversity, max Tanimoto similarity of 0.66
- High concentration collection (100 mM DMSO stock concentration -> up to 1 mM screening concentration)
- Application: Fragment screening
RANGE FINDER LIBRARY
Fragment enriched 41k small molecules library
- Fragment enriched (25% MW < 300 g/mol
- Sorted by size: 10,000 Fragments can be screened separately
- High sp3 fraction, average sp3 fraction = 0.42
- Applications: Combination of fragment and small molecule screen
- Screen of smaller library with high hit rates
SMALL MOLECULE LIBRARY
150k high quality small molecules
- High diversity
- Specific clustering concept (23,598 clusters, mean cluster size = 6)
- Additional cluster members available by expansion into full range of Enamine compounds
- Application: HTS
RANGE FINDER + SMALL MOLECULE LIBRARY
191k high quality small molecules (fragment enriched)
- Combination of range finder and small molecule diversity library
- Application: HTS
PROTEROS STATISTICS