MedChemExpress - Model Ajmaline -4360-12-7
Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia[1][2].MCE products for research use only. We do not sell to patients.
Ajmaline
MCE China：Ajmaline
Brand：MedChemExpress (MCE)
Cat. No.HY-B1167
CAS：4360-12-7
Synonyms：Cardiorythmine; (+)-Ajmaline
Purity：99.73%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia.
In Vitro：Electrophysiological experiments are performed with human embryonic kidney (HEK) cells (whole-cell patch clamp) and Xenopus oocytes (double-electrode voltage clamp) expressing wild-type and mutant HERG channels. Ajmaline blocks HERG currents with an IC50 of 1.0μM in HEK cells and 42.3μM in Xenopus oocytes[2].
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References：
[1]. Sparidans RW, et al. Liquid chromatographic assay with fluorescence detection to determine ajmaline in serum from patients with suspected Brugada syndrome. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878(23):2168-2172. [Content Brief]
[2]. Kiesecker C, et al. Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action. Naunyn Schmiedebergs Arch Pharmacol. 2004;370(6):423-435. [Content Brief]
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