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Azoxystrobin

MCE China：Azoxystrobin

Brand：MedChemExpress (MCE)

Cat. No.HY-B0849

CAS：131860-33-8

Purity：99.00%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.

In Vitro：Azoxystrobin (1, 5, 25 mg/L, 1 hour) significantly reduces the germination rate of C. macrocarpum spores and the length of mycelial growth in a dose-dependent manner. Azoxystrobin exhibits inhibitory effects on C. macrocarpum[2]. Azoxystrobin (25 mg/L, 1 hour) significantly delays the germination of A. alternata spores, reduces the final germination rate, and inhibits mycelial growth and papilla formation. Azoxystrobin demonstrates a clear inhibitory effect on A. alternata[2].

In Vivo：Azoxystrobin (0.5, 1, 10 mg/kg; Azoxystrobin solution is mixed with dry oat and administered orally; twice a week; 21 days) has a dose effect on the bacterial and fungal communities in the gut of E. crypticus, inducing the growth of pathogens, reducing the abundance of beneficial bacteria and disrupting the stability of the gut microecology[4]. Azoxystrobin (0, 2, 25, 50 mg/kg) inhibits the activity of urease, Invertase (HY-P2979), and phosphatase, and alters the relative abundance of soil microbial communities[3].

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References：

[1]. Enock Mpofu, et al. Azoxystrobin amine: A novel azoxystrobin degradation product from Bacillus licheniformis strain TAB7. Chemosphere. 2021 Jun;273:129663.  [Content Brief]

[2]. Bertelsen, J.R, et al. Fungicidal effects of azoxystrobin and epoxiconazole on phyllosphere fungi, senescence and yield of winter wheat. Plant Pathology, 50: 190-205.

[3]. Wang X, et al. Fungicide azoxystrobin induced changes on the soil microbiome[J]. Applied Soil Ecology, 2020, 145: 103343.

[4]. Zhang Q, et al. Oral azoxystrobin driving the dynamic change in resistome by disturbing the stability of the gut microbiota of Enchytraeus crypticus. J Hazard Mater. 2022 Feb 5;423(Pt B):127252.  [Content Brief]