MedChemExpress - Model Calcitonin (human) -21215-62-3
Calcitonin (human) is a hypocalcemic hormone. Calcitonin can lower blood calcium levels and inhibit bone resorption. Calcitonin can be used in hypercalcemia or osteoporosis research[1][2][3].MCE products for research use only. We do not sell to patients.
Calcitonin (human)
MCE China：Calcitonin (human)
Brand：MedChemExpress (MCE)
Cat. No.HY-P2273
CAS：21215-62-3
Purity：99.70%
Storage：Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Calcitonin (human) is a hypocalcemic hormone. Calcitonin can lower blood calcium levels and inhibit bone resorption. Calcitonin can be used in hypercalcemia or osteoporosis research.
In Vitro：Calcitonin shows a potent inhibitory action on osteoclast mediated bone resorption[1].
In Vivo：Calcitonin (oral gavage; 2 mg/kg; once daily; 9 w) can inhibit cartilage degradation and prevent cartilage erosion[3].
Sequence：Cys-Gly-Asn-Leu-Ser-Thr-Cys-Met-Leu-Gly-Thr-Tyr-Thr-Gln-Asp-Phe-Asn-Lys-Phe-His-Thr-Phe-Pro-Gln-Thr-Ala-Ile-Gly-Val-Gly-Ala-Pro-NH2 (Disulfide bridge:Cys1-Cys7)
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References：
[1]. Sexton PM, et al. Calcitonin. Current Medicinal Chemistry, 01 Nov 1999, 6(11):1067-1093. [Content Brief]
[2]. Foster GV. Calcitonin. A review of experimental and clinical investigations. Postgrad Med J. 1968 May;44(511):411-22. [Content Brief]
[3]. Bodil-Cecilie Sondergaard, et al. The effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat model. Arthritis Rheum. 2007 Aug;56(8):2674-8. [Content Brief]
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