MedChemExpress - Model Cefotiam -61622-34-2
Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria[1][2].MCE products for research use only. We do not sell to patients.
Cefotiam
MCE China：Cefotiam
Brand：MedChemExpress (MCE)
Cat. No.HY-B0734
CAS：61622-34-2
Synonyms：SCE-963; Cefotiam Dihydrochloride
Storage：Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Cefotiam (SCE-963) is a parenteral cephalosporin antibiotic. Cefotiam has broad-spectrum activity against Gram-positive and Gram-negative bacteria.
In Vitro：Cefotiam (SCE-963; 0-6.25μg/mL; 8 h) has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849[1]. Cefotiam (0-6.25μg/mL; 8 h) has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL). All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL[2].
In Vivo：Cefotiam (SCE-963; 12.5-800 mg/kg; i.h.; twice a day for 5 d) can cure urinary tract infection with P. mirabilis in mice to reduce or complete eradicate bacteria in the bladder walls and kidneys[1].
IC50 & Target：β-lactam
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References：
[1]. Iwahi T, et, al. Comparative activities of cefotiam and cefazolin against urinary tract infections with Proteus mirabilis in mice. Antimicrob Agents Chemother. 1980 Aug;18(2):257-63. [Content Brief]
[2]. Watt B, et, al. In-vitro activity of cefotiam against bacteria of clinical interest. J Antimicrob Chemother. 1982 Nov;10(5):391-5. [Content Brief]
Brand introduction:
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