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MedChemExpress - Model Chlorhexidine (digluconate) -18472-51-0
Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis[1][2][3].MCE products for research use only. We do not sell to patients.
Chlorhexidine (digluconate) (20% in water)
MCE China：Chlorhexidine (digluconate) (20% in water)
Brand：MedChemExpress (MCE)
Cat. No.HY-B0608
CAS：18472-51-0
Purity：99.23%
Storage：Solution, -20°C, 2 years
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis.
In Vitro：Chlorhexidine digluconate (0.00001%, 0.00005%, 0.0001%, 0.0005%; 1-4 h) demonstrates a cytotoxic effect on CHO cells. Chlorhexidine digluconate reduces the activity of dehydrogenase of CHO cells in a dose-dependent and a time-dependent manner[2]. Chlorhexidine digluconate (0.00005%, 0.0001%, 0.0005%; 1 h) causes the amount of cell apoptosis of about 1.62%, 5.51%, and 5.47%, respectively. The amount of cell necrosis was 2.38%, 8.62%, and 22.50%, respectively[2].
In Vivo：Chlorhexidine gluconate (0.05%, 0.025%; One-time intraperitoneal injection) with 0.05% lavage has significantly lower incidence of postoperative intra-abdominal abscesses compared with the mice that had saline lavage only[1].
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References：
[1]. Wael E Shams, et al. Peritoneal Lavage Using Chlorhexidine Gluconate at the End of Colon Surgery Reduces Postoperative Intra-Abdominal Infection in Mice. J Surg Res. 2015 May 1;195(1):121-7. [Content Brief]
[3]. Hon-Yeung Cheung, et al. Differential actions of chlorhexidine on the cell wall of Bacillus subtilis and Escherichia coli. PLoS One. 2012;7(5):e36659. [Content Brief]
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