MedChemExpress - Model Corynoxine B -17391-18-3
Corynoxine B is a natural alkaloid and autophagy inducer that can improve Mn induced cellular autophagy dysregulation and enhance clearance of alpha synuclein (alpha syn) in Parkinson's disease mice[1][3].MCE products for research use only. We do not sell to patients.
Corynoxine B
MCE China：Corynoxine B
Brand：MedChemExpress (MCE)
Cat. No.HY-N0901A
CAS：17391-18-3
Purity：99.76%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Corynoxine B is a natural alkaloid and autophagy inducer that can improve Mn induced cellular autophagy dysregulation and enhance clearance of alpha synuclein (alpha syn) in Parkinson's disease mice[1][3].
In Vitro：Corynoxine B (25-100 μM, 2 h) can improve Mn induced autophagy dysregulation and neurotoxicity in SH-SY5Y human neuroblastoma cells[1]. Corynoxine B can enhance the expression of BECN1 protein and restore autophagy inhibition caused by overexpression of SNCA/α-synuclein (α-syn) in PC12 cells[2].
In Vivo：Corynoxine B (5-20 mg/kg, i.p.) enhances autophagy of alpha synuclein (alpha syn) clearance in Parkinson's disease mice by targeting HMGB1/2[3].
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References：
[1]. Yan D, et al. Corynoxine B ameliorates HMGB1-dependent autophagy dysfunction during manganese exposure in SH-SY5Y human neuroblastoma cells. Food Chem Toxicol. 2019 Feb;124:336-348. [Content Brief]
[2]. Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10(1):144-54. doi: 10.4161/auto.26751. Epub 2013 Jan 1. Erratum in: Autophagy. 2015;11(9):1708. [Content Brief]
[3]. Zhu Q, et al. Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease. Acta Pharm Sin B. 2023 Jun;13(6):2701-2714. [Content Brief]
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