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MedChemExpressModel CVN636 -2226732-62-1

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CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC50 value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability[1].
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CVN636

MCE China:CVN636

Brand:MedChemExpress (MCE)

Cat. No.HY-153615

CAS:2226732-62-1

Purity:99.47%

Storage:Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Shipping:Room temperature in continental US; may vary elsewhere.

Description:CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC50 value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability.

In Vivo:CVN636 (0.3-3 mg/kg; p.o.) reduces ethanol self-administration in msP rats[1].

IC50 & Target:hu mGluR7 7 nM (EC50)

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References:

[1]. Ayscough AP, et, al. Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449.  [Content Brief]

[2]. Dickson L, et, al. Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449.  [Content Brief]

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•   The biological activity of the products has been verified by the experiments of customers in various countries;
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