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MedChemExpress - Model Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA -199807-33-5

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia[1].

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA

MCE China：Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA

Brand：MedChemExpress (MCE)

Cat. No.HY-P1613A

CAS：199807-33-5

Synonyms：Cyclo(RGDfV) TFA; C(RGDfV) TFA

Purity：99.77%

Storage：Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA))is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia.

In Vitro：Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents[1].

IC50 & Target：αvβ3[1] In Vitro Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (Cyclo(RGDfV) (TFA)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA Related Antibodies Cell Cycle Analysis[1] Cell Line: MV4-11 cells

References：

[1]. Shen ZH, et al. Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12(5):3278-3284. [Content Brief]

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MedChemExpress - Model Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA -199807-33-5

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Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA