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MedChemExpress - Model Dehydroepiandrosterone sulfate -651-48-9
Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses[1][2][3].MCE products for research use only. We do not sell to patients.
Dehydroepiandrosterone sulfate
MCE China：Dehydroepiandrosterone sulfate
Brand：MedChemExpress (MCE)
Cat. No.HY-113416
CAS：651-48-9
Synonyms：DHEA sulfate; Prasterone sulfate
Purity：99.28%
Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping：Room temperature in continental US; may vary elsewhere.
Description：Dehydroepiandrosterone sulfate, a neuroactive neurosteroid, plays a major role in brain development and aging by influencing the migration of neurons, arborization of dendrites, and formation of new synapses.
In Vitro：Dehydroepiandrosterone sulfate (DHEAS) selectively increased the length of neurites containing the dendritic marker MAP-2[1].?Dehydroepiandrosterone sulfate (DHEAS) has been reported to increase neuronal excitability (firing rate) when directly applied to septal-preoptic neurons[1].?Dehydroepiandrosterone (DHEA) is produced in prodigious quantities by the human?adrenal, principally as the 3-sulfoconjugate DHEA sulfate (DS) during intrauterine life[2].?Dehydroepiandrosterone sulfate (DHEAS) is generally nontoxic and lacks adverse side effects even when it is administered chronically[3].
In Vivo：DHEAS chronic administration produces a dose-dependent effect on performance[3].
IC50 & Target：Human Endogenous Metabolite
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References：
[1]. E E Baulieu, et al. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4089-91. [Content Brief]
[2]. C R Parker Jr, et al. Dehydroepiandrosterone and dehydroepiandrosterone sulfate production in the human adrenal during development and aging. Steroids. 1999 Sep;64(9):640-7. [Content Brief]
[3]. Stuart W Hoffman, et al. The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats. J Neurotrauma. 2003 Sep;20(9):859-70. [Content Brief]
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