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Deoxycorticosterone acetate

MCE China：Deoxycorticosterone acetate

Brand：MedChemExpress (MCE)

Cat. No.HY-B1472

CAS：56-47-3

Synonyms：11-Deoxycorticosterone acetate; DOC acetate; Cortexone acetate

Purity：99.57%

Storage：Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months

Shipping：Room temperature in continental US; may vary elsewhere.

Description：Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria.

In Vivo：Deoxycorticosterone acetate (DOCA) can be used to induce hypertension models[3][4]. .f12{ font-size: 12px; } .fwb{ font-weight: bold; } .lh22{ line-height: 22px;; } .lh23 { line-height: 23px; } .pl13{ padding-left: 13px;; } .part { margin-top: 18px; } .mold-first-tit { width: 100%; height: 44px; line-height: 44px; background: #F9F7FB; border-bottom: 1px solid #EBE4F6; padding-left: 16px; box-sizing: border-box; margin-bottom: 17px; } .mold-second-tit:before { content:""; width: 6px; height: 6px; display: inline-block; border-radius: 50%; background: rgba(255,102,0,0.4); margin-right: 12px; position: relative; top: -3px; } .lft-border { border-left: 1px dotted #EBE4F6; padding-right: 12px; margin-left: 3px; box-sizing: border-box; padding-bottom: 12px; } /* .part .dec:last-child { border-bottom: 0; } */ .dec { margin: 10px 15px 0; padding-bottom: 10px; border-bottom: 1px dashed #EBE4F6; } .btm-border { border-left: 1px dashed #EBE4F6; } .text-bg { margin-top: 10px; background: #FFFBF1; padding: 14px; border-bottom: 0; position: relative; } .text-note-bg { margin-top: 10px; background: #FFFDF7; padding: 12px; border-bottom: 0; position: relative; } .text-note { width: 51px; height: 20px; line-height: 20px; background: #FFE2AA; text-align: center; border-radius: 0 0 8px 0; position: absolute; top: 0; left: 0; } .text-note-dec { margin-top: 15px;; } Induction of hypertension[3][4] Background Deoxycorticosterone acetate (DOCA) inhibits the renin-angiotensin system, resulting in low plasma renin activity, thereby mediating an increase in blood pressure Specific Mmodeling Methods Rat: Sprague-Dawley • Male • ① 250-300 g & ② 160-180 gAdministration: ① 100 mg sustained-release DOCA capsules were implanted subcutaneously and drinking water was replaced with 1% saline; continued for 21 days. ② 15 mg/kg • subcutaneously implanted • drinking water was replaced with 1% saline; twice a week for 2 weeks. Note Pretreatment: conduct a right nephrectomy in Sprague-Dawley rats. Modeling Indicators Pathological changes: systolic blood pressure increase, superoxide (vascular O2) increase Correlated Product(s): / Opposite Product(s): Atrasentan (HY-15403)A-192621 (HY-120295)

IC50 & Target：Human Endogenous Metabolite

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References：

[1]. Lother A, et al. Deoxycorticosterone Acetate/Salt-Induced Cardiac But Not Renal Injury Is Mediated By Endothelial Mineralocorticoid Receptors Independently From Blood Pressure. Hypertension. 2016 Jan;67(1):130-8.  [Content Brief]

[2]. Lu NZ, et al. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol Rev. 2006 Dec;58(4):782-97.  [Content Brief]

[3]. M J Somers, et al. Vascular Superoxide Production and Vasomotor Function in Hypertension Induced by Deoxycorticosterone Acetate–Salt. Circulation. 2000 Apr 11;101(14):1722-8.  [Content Brief]

[4]. Y Matsumura, et al. Different Contributions of Endothelin-A and Endothelin-B Receptors in the Pathogenesis of Deoxycorticosterone Acetate–Salt–Induced Hypertension in Rats. Hypertension. 1999 Feb;33(2):759-65.  [Content Brief]