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MedChemExpress - Model Itaconic acid -97-65-4
Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect[1][2][4][5].MCE products for research use only. We do not sell to patients.
Itaconic acid
MCE China:Itaconic acid
Brand:MedChemExpress (MCE)
Cat. No.HY-Y0520
CAS:97-65-4
Synonyms:Methylenesuccinic acid
Purity:99.70%
Storage:4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Shipping:Room temperature in continental US; may vary elsewhere.
Description:Itaconic acid, a precursor of polymers, chemicals, and fuels, can be synthesized by many fungi. Itaconic acid also is a macrophage-specific metabolite. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. Itaconic acid has anti-inflammatory, anti-microbial and immunomodulatory effect.
In Vitro:Itaconic acid (2–8 mM, 24 h) induces ferroptosis by activating ferritinophagy in PANC1 cells[3]. Itaconic acid (10 mM, 24 h) inhibits LPS-induced inflammatory cytokines in RAW264.7 cells[4]. Itaconic acid (10 mM, 24 h) promotes the pentose phosphate pathway (PPP) and NADPH oxidase activity in RAW264.7 cells[4]. Itaconic acid (10 mM, 24-72 h) inhibits cell viability of cerebellar granule cells (CGC) and inhibits ADP-stimulated respiration in permeabilized CGC cells[5].
IC50 & Target:Human Endogenous Metabolite
Hot selling product:Cyclizine | Mevastatin | Insulin degludec | Amrubicin | Erucic acid | Mogamulizumab | Entecavir | Glycodeoxycholic Acid | NHS-SS-biotin | Carcinoembryonic Antigen (CEA)
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
References:
[1]. Weiss JM, et, al. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. J Clin Invest. 2018 Aug 31;128(9):3794-3805. [Content Brief]
[2]. Zhao M, et, al. Itaconic acid production in microorganisms. Biotechnol Lett. 2018 Mar;40(3):455-464. [Content Brief]
[3]. Qu C, et al. Itaconic acid induces ferroptosis by activating ferritinophagy. Biochem Biophys Res Commun. 2021 Oct 25;583:56-62. [Content Brief]
[4]. Zhu X, et al. Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS. Sci Rep. 2021 Sep 13;11(1):18173. [Content Brief]
[5]. Umbrasas D, et al. Effects of itaconic acid on neuronal viability and brain mitochondrial functions. J Bioenerg Biomembr. 2021 Oct;53(5):499-511. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。
